Technology
Our technology covers methods of synthesizing lipids, specialty (ionizable) lipids, LNP compositions, & modifications of mRNA
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Our toolbox covers it all
No need to multi-source.
With our one-stop-shop IP portfolio, we are equipped to custom design an LNP system that will address all your needs — in terms of both cargo and delivery to your target tissue.
Get it piecemeal from other sources…
… or get it all from NTx
A platform for success
Our unique platform technology gets your life-changing gene therapy into the clinic… fast
Every NanoVation Therapeutics™ innovation is underpinned by:
- novel mRNA caps to increase translation;
- proprietary high-yield synthesis pathways;
- surface-modifying lipids with improved tolerability compared to PEG-lipids; and
- increased potency standards compared to commercial formulations.
We have the expertise
Synthetic Organic Chemistry
In-house small-molecule, lipid, & nucleoside synthesis capability by a team with 30+ years’ experience in the field.
Outstanding portfolio of novel, proprietary, economical lipids for nucleic acid delivery with proven efficacy in vivo & in vitro.
Pre-Clinical Studies
LNP transfection in preclinical systems.
Pharmacokinetics, efficacy and biodistribution of LNPs characterized in various systems.
Lead LNP formulations identified for cell type-specific and tissue-specific delivery.
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Unique ionizable lipid libraries
NTx uses bucket chemistry to create extensive lipid libraries at a low cost, with easier synthesis, at a higher yield, and with a higher therapeutic index.
High-yield✓
Biodegradable✓
Improved potency✓
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LNP compositions
NTx develops scalable, nucleic acid-agnostic lipid nanoparticle (LNP) formulations customized for specific tissues, different nucleic acid payloads and routes of administration.
- Novel in-house lipids to formulate lipid nanoparticles (LNPs) encapsulating a variety of payloads (siRNA, mRNA, pDNA, etc.).
- Formulated LNPs analyzed for nucleic acid and lipid content, entrapment, particle size and polydispersity.
- LNP compositions for hepatropic and local delivery.
The long-circulating LNP (lcLNP™)
NanoVation’s flagship technology – the long-circulating LNP (lcLNP™) – enables the functional delivery of nucleic acids to extrahepatic tissues including bone marrow, tumors, and skin.
- Extended systemic circulation for efficient extrahepatic delivery.
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Surface modifications
NTx expands the range of surface modifications to improve tolerability and increase target specificity.
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mRNA modifications
NTx develops new mRNA modifications and manufacturing strategies that improve expression kinetics and storage stability while increasing translation and cellular specificity.
- In-house in vitro mRNA synthesis from DNA templates with optimized translational efficiency and stability
- Different mRNA constructs available for a variety of biological applications.
- In vitro transcribed mRNA characterized for purity, capping efficiency and endotoxin levels
- Novel proprietary RNA caps that greatly increase the efficiency of mRNA translation