Technology
We have the know-how, technology and IP to design a customized nucleic acid delivery technology for your therapeutic application
The NanoVationtx™ difference
Bringing your medicine to life
NanoVation TherapeuticsTM is the one place you can get everything you need to move your genetic medicine from the lab to the people who need it.
From concept…
Fit-for-Purpose
Customized development of best-in-class LNP delivery technologies
Unparalleled expertise in rational design of LNPs with improved therapeutic index
Beyond the Liver
Platform technologies for nucleic acid delivery to a variety of tissues
lcLNP™ technology with improved potency & safety for extrahepatic targets
Delivery Toolbox
Comprehensive IP portfolio providing a clear path to commercialization
Leading patent position covering ionizable lipids, LNP compositions, surface & RNA modifications
Fit-for-Purpose
Customized development of best-in-class LNP delivery technologies
Unparalleled expertise in rational design of LNPs with improved therapeutic index
Beyond the Liver
Platform technologies for nucleic acid delivery to a variety of tissues
lcLNP™ technology with improved potency & safety for extrahepatic targets
Delivery Toolbox
Comprehensive IP portfolio providing a clear path to commercialization
Leading patent position covering ionizable lipids, LNP compositions, surface & RNA modifications
Fit-for-Purpose
Customized development of best-in-class LNP delivery technologies
Unparalleled expertise in rational design of LNPs with improved therapeutic index
Beyond the Liver
Platform technologies for nucleic acid delivery to a variety of tissues
lcLNP™ technology with improved potency & safety for extrahepatic targets
Delivery Toolbox
Comprehensive IP portfolio providing a clear path to commercialization
Leading patent position covering ionizable lipids, LNP compositions, surface & RNA modifications
The NanoVationtx™ toolbox
Our toolbox covers it all
No need to multi-source. Our technology covers methods of synthesizing lipids, specialty (ionizable) lipids, LNP compositions, and modifications of mRNA.
With our one-stop-shop IP portfolio, we are equipped to custom design an LNP system that will address all your needs — in terms of both cargo and delivery to your target tissue.
Get it piecemeal from other sources…
Technologies to enable life-changing genetic medicines
NanoVation TherapeuticsTM technologies have demonstrated improvements over conventional LNP formulations for nucleic acid delivery to tissues beyond the liver (extrahepatic tissues) such as bone marrow, immune compartments, and solid tumors.
Our platform technologies are well-suited to rare genetic disorders, metabolic diseases, and other conditions requiring precise nucleic acid delivery.
A platform for success
Our unique platform technology gets your life-changing gene therapy into the clinic… fast
Workplan development
Synthetic chemistry & RNA synthesis
Formulation
Workplan development
Synthetic chemistry & RNA synthesis
Formulation
Preclinical studies
Scale-up & manufacturing
Safety & efficacy studies
Preclinical studies
Scale-up & manufacturing
Safety & efficacy studies
Our toolbox
Unique ionizable lipid libraries
NanoVation TherapeuticsTM uses bucket chemistry to create extensive lipid libraries at a low cost, with easier synthesis, at a higher yield, and with a higher therapeutic index.
- High-yield
- Biodegradable
- Improved potency
LNP compositions
- Rationally designed LNPs for a variety of tissues including: delivery to bone marrow, immune compartments, and solid tumors.
- Nucleic agnostic: Encapsulating a variety of payloads (siRNA, mRNA, DNA, etc.).
- Rigorously characterized for nucleic acid and lipid content, entrapment, particle size and polydispersity.
The long-circulating LNP (lcLNP™)
NanoVation’s flagship technology – the lcLNP™ – enables the functional delivery of nucleic acids to extrahepatic tissues including bone marrow, tumors, and skin.
- Extended systemic circulation for efficient extrahepatic delivery.
- Improved safety profile.
- Enhanced efficacy in extrahepatic tissues.
Surface modifications
NanoVation TherapeuticsTM expands the range of surface modifications to improve tolerability and increase target specificity. This includes PEGless LNP compositions as well as opportunities to modify our lcLNP technology with targeting ligands.
mRNA modifications
- In-house in vitro mRNA synthesis from DNA templates with optimized translational efficiency and stability
- Different mRNA constructs available for a variety of biological applications.
- In vitro transcribed mRNA characterized for purity, capping efficiency and endotoxin levels.
- Novel proprietary RNA caps that greatly increase the efficiency of mRNA translation.